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doi: 10.1089/ars.2012.5143 197 YasuhikoH

The transcriptomic results were verified by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) analysis (Fig

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On the one hand, cancer metabolism-related signals or metabolites affect the activation and function of microenvironmental antitumor immune cells (T cells and NK cells) in the TME, and on the other hand, cancer-associated stromal cells, such as CAFs, and immunosuppressive cells (M2 macrophages and MDSCs) reshape the local metabolic environment and oncogenic pathways, further promoting malignant tumor progression